CD34+细胞移植治疗慢性心力衰竭的研究进展
Research progress of CD34+cell transplantation for chronic heart failure
王华 1刘永铭2
作者信息
- 1. 兰州大学第一临床医学院,甘肃兰州 730000
- 2. 兰州大学第一医院老年心血管科,甘肃兰州 730000
- 折叠
摘要
CD34+细胞具有微循环再生潜能和旁分泌抗炎作用,而在心力衰竭患者中,参与血管修复的CD34+细胞数量和功能下降.多项试验发现在慢性心力衰竭患者中进行CD34+细胞移植治疗可以提高心肌性能,减少神经体液激活,并提高锻炼能力和生活质量,甚至改善心力衰竭群体的生存率.CD34+细胞移植可能成为慢性心力衰竭患者未来可选择的治疗方案.
Abstract
CD34+cells have microcirculatory regenerative potential and paracrine anti-inflammatory effects,but the number and function of CD34+cells involved in vascular repair are decreased in patients with heart failure.Multiple trials have found that CD34+cell transplantation therapy in patients with chronic heart failure can improve myocardial performance,reduce neurohumoral activation,improve exercise capacity and quality of life,and even improve the survival rate in patients with heart failure.CD34+cell transplantation may be a future treatment option for patients with chronic heart failure.
关键词
抗原,CD34/细胞移植/心力衰竭Key words
antigens,CD34/cell transplantation/heart failure引用本文复制引用
基金项目
甘肃省重点研发计划(20YF8FA079)
出版年
2024
NETL
NSTL
万方数据