The new antidepressant toludesvenlafaxine,also known as ansofaxine,is a triple monoaminergic reuptake inhibitor independently developed in China.It can play an antidepressant effects by blocking the reuptake of the three neurotransmitters by combining with the serotonin transporter,noradrenaline,and dopamine transporter.Toludesvenlafaxine has a rapid effect,which can significantly improve the low mood,anhedonia,lack of motivation and other symptoms of patients with depressive disorders,relieve the associated anxiety symptoms,and is not easy to lead to sexual dysfunction and other adverse reactions in the treatment process.While using toludesvenlafaxine,clinicians should start titration with a low dose and assess the risk of mania during the course of treatment,and pay attention to whether the drug could cause psychotic symptoms,since it acts on the dopamine pathway.