Effects of ciprofol in intracranial aneurysm embolization
AIM To observe the anesthetic effect of ciprofol in intracranial aneurysm embolization.METHODS One hundred and twenty patients undergoing intracranial aneurysm embolization,ASA Ⅰ or Ⅱ,were randomly divided into control group and experimental group(n=60,each group).During anesthesia induction,patients were given with midazolam 0.04 mg·kg-1,sufentanil 0.25 µg·kg-1,ciprofol 0.4 mg·kg-1(experimental group)or propofol 2.0 mg·kg-1(control group),and rocuronium 0.6 mg·kg-1.During anesthesia maintenance,all patients were maintained with remifentanil 1 μg·kg-1·h-1 and cisatracurium 0.1 mg·kg-1·h-1,combined with ciprofol 0.8 mg·kg-1·h-1(experimental group)or propofol 5 mg·kg-1·h-1(control group).The bispectral index(BIS)was maintained between 40 and 60 by adjusting the pumping speed during the operation.The changes of vital signs and BIS were observed.The anesthesia induction time,awakening time,and Ramsay sedation score after extubation were recorded.And the occurrence of adverse reactions was also observed.RESULTS There was no significant difference in systolic blood pressure(SBP),diastolic blood pressure(DBP),and heart rate(HR)between the two groups before anesthesia,after anesthesia induction,after tracheal intubation,at the end of operation,and after tracheal extubation.The BIS at the end of operation in the experimental group was lower than that in the control group(P＜0.05).The fluctuation value of SBP,DBP,and HR during anesthesia induction in the control group was significantly greater than that in the experimental group(P＜0.05).The recovery time of the experimental group was slightly longer while the use of sedatives was less than that of the control group(P＜0.05).The incidences of post-induced hypotension,hypertension after intubation,and injection pain in the experimental group were lower than those in the control group(P＜0.05).CONCLUSION Ciprofol can be used in intracranial aneurysm embolization with outstanding sedative efficacy.The hemodynamics of patient is more stable,and the incidence of postoperative adverse reaction is low.
万方数据
维普
