首页|新型抗菌药物依拉环素的研究进展

新型抗菌药物依拉环素的研究进展

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依拉环素是一种新型全合成的含氟四环素类抗生素,具有广谱的抗菌活性。现有的临床试验表明,依拉环素在治疗各类复杂性感染中具有很好的有效性和安全性,尤其在针对多药耐药菌方面应用前景良好。本文从该药的化学结构、作用机制、抗菌谱、药动学/药效学、临床应用、耐药性等方面进行综述,为临床用药提供依据和参考。
Research progress of a new antibacterial drug eravacycline
Eravacycline is a new class of fully synthetic fluortetracycline antibiotics with broad-spectrum antibacterial activity.The existing clinical trials have shown that eravacycline has good efficacy and safety in the treatment of various complex infections,especially in the application of multi-drug resistant bacteria.In this paper,the chemical structure,mechanism of action,antibacterial spectrum,pharmacokinetics/pharmacodynamics,clinical application,and drug resistance of eravacycline were reviewed in order to provide basis and reference for clinical drug use.

eravacyclinepharmacological mechanism of actionclinical studydrug resistance,bacterial

冯洁、谢俊艳、时友忠、安洪亮

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南京梅山医院药剂科,江苏南京 210039

依拉环素 药理作用机制 临床研究 抗药性,细菌

2024

中国新药与临床杂志
中国药学会 上海市食品药品监督管理局科技情报研究所

中国新药与临床杂志

CSTPCD北大核心
影响因子:0.967
ISSN:1007-7669
年,卷(期):2024.43(9)