Effect of lactic acid on nicotine release in different forms of electrical heated cigarettes aerosol
[Background]In order to control the balance between the impact and irritation of the heated cigarettes.[Methods]the effect of acetic acid,propionic acid and lactic acid on the nicotine release for different forms of aerosols was investigated.Moreover,T the dichloromethane-water biphase extraction system was used to determine the free nicotine in the heated cigarettes.[Results]The results showed that:①Lactic acid significantly changed the free nicotine release for the aerosols of electrical heated cigarettes.2In addition to the total nicotine in tobacco material,the pH value,free nicotine,free nicotine coefficient of the tobacco materials as well as the pH value,free nicotine,total nicotine,free nicotine coefficient and nicotine transfer rate of the aerosols all decreased with the increase of lactic acid.③There was a strong linear dose-effect relationship between the lactic acid amount and the key indicators for tobacco materials and aerosols.④The free nicotine coefficient showed an identifiable downward trend with the increase of puff sequence,and the decline trend of the first six puffs were more obvious,i.e.,the free nicotine tended to be released in the first six puffs from the tobacco materials.[Conclusion]Quantitative control of total nicotine and free nicotine release in aerosols can be achieved through lactic acid,balancing strength and stimulation in heated cigarettes to improve sensory comfort in high-nicotine release heated cigarettes.
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