Clinical application study of meropenem in the treatment of severe pneumonia in chil-dren
Objective To investigate the clinical effect of meropenem in the treatment of children with severe pneumonia.Methods A total of 80 children admitted to our hospital and diagnosed with severe pneumonia from January 2020 to January 2022 were selected and randomly divided into a control group and an observation group,with 40 children in each group.The control group was treated with cefoperazone sulbactam,while the observation group received a combination of cefoperazone sulbactam and meropenem.The clinical efficacy,levels of serum procalcitonin(PCT),interleukin-13(IL-13),lipid peroxidation(LPO),superoxide dismutase(SOD),and blood gas analysis indicators were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group,with a statistically significant difference(χ2=7.813,P＜0.05).After treatment,the levels of PCT,IL-13,and LPO in the observation group were lower,while the level of SOD was higher compared to the control group,with significant differences(t=8.729,10.766,11.695,8.780,all P＜0.05).The levels of arterial oxygen pressure(PaO2)and arterial oxygen saturation(SaO2)in the observation group were higher,and the level of arterial carbon dioxide pressure(PaCO2)was lower than that in the control group,with significant differences(t=7.783,6.340,9.506,all P＜0.05).Conclusion The combined treatment of cefoperazone sulbactam and meropenem in children with severe pneumonia can effectively improve the clinical condition and related biomarkers of children with severe pneumonia.
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