Objective To investigate the occurrence and risk factors of kidney injury in patients in the emergency resuscitation room.Method Clinical data of 266 patients admitted to the emergency resuscitation room of Mianyang Central Hospital of Sichuan Province from February 2022 to February 2023 were retrospectively analyzed.According to whether kidney injury occurred 48 h after entering the emergency resuscitation room,the study subjects were divided into occurrence group(95 cases with kidney injury)and non-occurrence group(171 cases without kidney injury).The occurrence of kidney injury in patients 48 h after entering emergency resuscitation room was analyzed.Univariate and multivariate logistic regression methods were used to analyze the independent risk factors of kidney injury in patients in the emergency resuscitation room.Result 48 h after entering the emergency resuscitation room,95 of 266 patients occurred kidney injury,the incidence of kidney injury was 35.71%,of which 46 patients(48.42%)had kidney injury of stage 1,and 29 patients(30.53%)had kidney injury of stage 2,and 20 patients(21.05%)had kidney injury of stage 3.The results of unifactorial analysis showed that the proportion of patients with age>60 years old,the proportion of patients with diabetes mellitus,the proportion of patients with sepsis,the APACHE Ⅱ score,serum creatinine,the proportion of nephrotoxic drugs,the proportion of vasoactive drugs,and the proportion of indentured catheters were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that age>60 years old,increased APACHE Ⅱ score,increased serum creatinine level,application of nephrotoxic drugs,application of vasoactive drugs,indentured catheters were independent risk factors for kidney injury in emergency resuscitation room patients(P<0.05).Conclusion The incidence of kidney injury was higher in emergency resuscitation room patients,and the independent risk factors for kidney injury were increased APACHE Ⅱ score,increased serum creatinine level,age>60 years old,application of nephrotoxic drugs,application of vasoactive drugs,indentured catheters.