Therapeutic effect of rivaroxaban combined with stent implantation in the treatment of lower limb arteriosclerosis obliterans and its impact on vascular endothelial function and hemodynamic indicators in patients
Objective To explore the efficacy of rivaroxaban combined with stent implantation in the treatment of lower limb arteriosclerosis obliterans,and to observe and analyze the impact of combined treatment on vascular endothelial function and hemodynamic indicators in patients.Method One hundred and eight patients with lower limb arteriosclerosis obliterans admitted to our hospital from September 2021 to April 2023 were selected as the research subjects and randomly divided into an observation group and a control group,with 54 patients in each group.Both groups of patients underwent stent implantation for treatment,and received oral administration of baiaspirin(100 mg/d)after the surgery,while the observation group received postoperative treatment in combination with rivaroxaban(5 mg/d).Compare the clinical efficacy of treatment between two groups of patients;Observe the changes in vascular endothelial function and hemodynamic indicators before and after 1 month of treatment in both groups of patients,and the occurrence of postoperative complications.Result The total effective rate of treatment in the observation group was significantly higher than that in the control group(90.74%vs 75.93%,χ2=4.2667,P=0.0389).After treatment,the nitroglycerin-mediated dilation(NMD),flow-mediated dilation(FMD)and nitric oxide(NO)level in both groups significantly increased,and the observation group showed a more significant increase compared to the control group(P＜0.05).The endothelin(ET)levels in both groups were significantly reduced compared to before treatment,and the observed group showed a more significant decrease compared to the control group(P＜0.05).After treatment,the inner diameter and blood flow of the dorsalis pedis artery in both groups of patients significantly increased,and the observation group showed a more significant increase compared to the control group(P＜0.05).The peak blood flow velocity significantly decreased,and the observation group showed a more significant decrease compared to the control group(P＜0.05).The total incidence of complications in the postoperative observation group was significantly lower than that in the control group(5.56%vs 20.37%,χ2=5.2523,P=0.0219).Conclusion The combination of Levofloxacin and stent implantation can improve the clinical efficacy of treating lower limb arteriosclerosis obliterans,significantly improve vascular endothelial function and hemodynamic indicators in patients,and help reduce the incidence of complications.It is worthy of clinical promotion and application.
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