The application effect of different doses of esketamine combined with sufentanil in postoperative patient-controlled intravenous analgesia for burn patients
Objective To explore the application effect of different doses of esketamine combined with sufentanil in postoperative patient-controlled intravenous analgesia for burn patients.Method 104 burn patients admitted to the Zhangjiakou First Hospital from January 2022 to January 2023 were selected as the study objects.They were divided into group A,group B,group C and group D by random number table method,with 26 cases in each group.Group A was treated with 2 μg/kg sufentanil PCIA after surgery.Group B was treated with 0.75 mg/kg esketamine and 1.5 μg/kg sufentanil PCIA after surgery.Group C was treated with 1.0 mg/kg esketamine and 1.5 μg/kg sufentanil PCIA after surgery.Group D was treated 1.5 mg/kg esketamine and 1.5 μg/kg sufentanil PCIA after surgery.VAS scores at different time points after surgery,stress response indexes(NE,COR,SOD,AOPPs)before and after surgery,hemodynamic indexes(SBP,HR,MAP)before and after surgery,sedation effect 48 h after surgery,and the occurrence of postoperative adverse reactions in the four groups were compared and analyzed.Result At 12,24 and 48 h after surgery,the VAS scores in group B,group C and group D were lower than those in group A,with statistical significance(P＜0.05),while there were no statistical significances in groups B,group C and group D(P＞0.05).24 h after surgery,the levels of NE,COR and AOPPs in group B,group C and group D were lower than those in group A,and those in group D were lower than those in group B and group C,with statistical significance(P＜0.05).The SOD level of group B,group C and group D was higher than that of group A,and group D was higher than that of group B and group C,the differences were statistically significant(P＜0.05).48 h after surgery,SBP,HR in group B,group C and group D were lower than those in group A,and MAP,the rates of good sedation were higher than those in group A,with statistical significance(P＜0.05),while there were no statistical significances in SBP,HR,MAP and the rates of good sedation in group B,group C and group D(P＞0.05).There were no significant differences in the incidence of postoperative adverse reactions among the four groups(P＞0.05).Conclusion Different doses of esketamine combined with sufentanil can significantly reduce the degree of postoperative pain in burn patients,and enhance the sedation effect,and improve the hemodynamic level of patients,among which 1.5 mg/kg esketamine combined with sufentanil can reduce the stress response better,with good safety.
万方数据
维普
