Objective The aim of this experiment is to investigate the expression and clinical significance of CXCL5 in ESCC.Method A total of 74 patients with ESCC diagnosed in the Affiliated Hospital of Southwest Medical University from January 2020 to December 2021 were selected.The difference of CXCL5 expression in the surgically resected ESCC tissues and adjacent normal esophageal tissues was detected by the immunohistochemical method,and the relationship between CXCL5 expression in ESCC tissues and clinicopathological characteristics was analyzed.Result The expression level of CXCL5 in ESCC tissues(85.1%)was significantly higher than that in adjacent normal esophageal tissues(43.2%),the difference was statistically significant(P＜0.05).The expression level of CXCL5 in ESCC tissues was not correlated with gender,age,tumor diameter and nerve invasion(P＞0.05),but was correlated with tumor location,pathological differentiation,depth of invasion,presence of vasculature embolus and lymph node metastasis(P＜0.05).Bioinformatics analysis showed that high expression of CXCL5 was associated with poor prognosis of ESCC(P＜0.05).Conclusion CXCL5 expression is upregulated in ESCC tissue,and high expression of CXCL5 is associated with metastasis and poor prognosis of patients.
关键词
C-X-C趋化因子5/食管鳞状细胞癌/临床意义/病理特征
Key words
CXCL5/Esophageal squamous cell carcinoma/Clinical significance/Pathological features
维普
万方数据