Risk factors of freezing of gait in patients with Parkinson's disease
Objective To investigate the risk factors of freezing of gait(FOG)in patients with Parkinson's disease(PD).Method 52 PD patients admitted to China-Japan Friendship Hospital from July 2019 to July 2022 were selected as the research objects,and the research objects were divided into FOG group(with FOG,14 cases)and non-FOG group(without FOG,38 cases)according to whether with FOG.The clinical and imaging characteristics between non-FOG group and FOG group were compared and analyzed.The functional connections of basal forebrain were compared between non-FOG group and FOG group.Multivariate logistic regression method was used to analyze the independent influencing factors of FOG in PD patients.Result The MDS-UPDRS Ⅱ score in FOG group were higher than that in non-FOG group,with statistical significance(P＜0.05)and the functional connections between Ch4 and bilateral middle cingulate gyrus,anterior central gyrus and auxiliar motor area were lower than those in non-FOG group.Multivariate logistic regression analysis showed that MDS-UPDRS Ⅱ score and Ch4 functional connection were independent influencing factors for FOG in PD patients(P＜0.05).Conclusion Increased MDS-UPDRS Ⅱ score and decreased Ch4 functional connectivity were independent influencing factors for FOG in PD patients.
Parkinson's diseaseFreezing of gaitFunctional connectionRisk factors
万方数据
维普
