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主观体力疲劳在老年患者肌力与跌倒风险之间的中介效应分析

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目的 探究主观体力疲劳在老年患者肌力与跌倒风险之间的中介效应。方法 以2019年1月至2022年12月在首都医科大学附属北京友谊医院老年医学科住院的老年患者为研究对象,选取入院前1年有跌倒史的167例患者为病例组,同时选取入院前1年无跌倒史的167例患者为对照组。比较分析两组患者的临床特征。分析主观体力疲劳、肌力与老年患者跌倒风险的相关性。分析老年患者跌倒风险的独立影响因素。分析主观体力疲劳在老年患者肌力与跌倒风险之间的中介效应。结果 病例组患者的体重指数、肌力低于或小于对照组,年龄、主观体力疲劳比例大于或高于对照组,差异均有统计学意义(P<0。05)。Pearson相关性分析结果显示,老年患者的主观体力疲劳与肌力呈显著负相关(r=-0。243,P<0。05),与跌倒风险呈显著正相关(r=0。160,P<0。05);老年患者的肌力与跌倒风险呈显著负相关(r=-0。240,P<0。05)。多因素logistic回归分析结果显示,体重指数、肌力是老年患者跌倒风险的独立保护因素(P<0。05),主观体力疲劳是老年患者跌倒风险的独立危险因素(P<0。05)。Model 4中介模型分析结果显示,肌力对跌倒风险的直接预测作用显著(β=0。132,t=4。311,P=0。000),当加入中介变量后,肌力对跌倒风险的直接预测作用仍然显著(β=0。121,t=2。103,P=0。000),肌力对主观体力疲劳的预测作用显著(β=0。219,t=3。151,P=0。000),主观体力疲劳对跌倒风险的预测作用显著(β=0。052,t=3。912,P=0。000)。Bootstrap检验模型分析结果显示,肌力对跌倒风险的直接效应值为0。641(95%CI 0。615~0。853),主观体力疲劳对跌倒风险的中介效应值为0。326(95%CI 0。032~0。221),95%CI 不包含0,表明中介效应成立,且中介效应值占总效应的33。72%。结论 主观体力疲劳是老年患者肌力与跌倒风险之间的中介变量,临床应重视老年患者主观体力疲劳的评估与干预,从而有助于降低老年患者的跌倒风险。
Analysis of the mediating effect of subjective physical fatigue between muscle strength and fall risk in elderly patients
Objective To explore the mediating effect of subjective physical fatigue between muscle strength and fall risk in elderly patients.Method The elderly patients hospitalized in the Department of Geriatrics of Beijing Friendship Hospital,Capital Medical University from January 2019 to December 2022 were selected as the study objects.167 patients with a history of fall one year before admission were selected as the case group,and 167 patients with no history of fall one year before admission were selected as the control group.The clinical features in the two groups were compared and analyzed.To analyze the correlation between subjective physical fatigue,muscle strength and fall risk in elderly patients.The independent influencing factors of fall risk in elderly patients were analyzed.To analyze the mediating effect of subjective physical fatigue between muscle strength and fall risk in elderly patients.Result The body mass index,muscle strength in the case group were lower than those in control group,and the age,the proportion of subjective physical fatigue were higher than those in control group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that subjective physical fatigue was significantly negatively correlated with muscle strength(r=-0.243,P<0.05),and significantly positively correlated with fall risk(r=0.160,P<0.05).There was significant negative correlation between muscle strength and fall risk in elderly patients(r=-0.240,P<0.05).Multivariate logistic regression analysis showed that body mass index and muscle strength were independent protective factors for fall risk in elderly patients(P<0.05),and subjective physical fatigue was independent risk factor for fall risk in elderly patients(P<0.05).The results of Model 4 intermediary model analysis showed that muscle strength had a significant predictive effect on fall risk(β=0.132,t=4.311,P=0.000),and when the mediating variable was added,the direct predictive effect of muscle strength on fall risk was still significant(β=0.121,t=2.103,P=0.000).Muscle strength was significant in predicting subjective physical fatigue(β=0.219,t=3.151,P=0.000),and subjective physical fatigue was significant in predicting fall risk(β=0.052,t=3.912,P=0.000).The results of Bootstrap test model analysis showed that the direct effect value of muscle strength on fall risk was 0.641(95%CI 0.615-0.853),and the mediating effect value of subjective physical fatigue was 0.326(95%CI 0.032-0.221),and 95%CI did not contain 0,indicating that the mediating effect was established.The intermediate effect accounted for 33.72%of the total effect.Conclusion Subjective physical fatigue is the mediating variable between muscle strength and fall risk in elderly patients.Clinical evaluation and intervention of subjective physical fatigue in elderly patients should be paid more attention,so as to help reduce the fall risk of elderly patients.

Subjective physical fatigueMuscle strengthFall riskElderly patientsMediating effect

曹炜、王晶、王娟、毕莉莉、齐瑶、纪伟

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首都医科大学附属北京友谊医院老年医学科,北京 100050

主观体力疲劳 肌力 跌倒风险 老年患者 中介效应

首都医科大学附属北京友谊医院科研启动基金

yyqdkt2019-59

2024

中国医刊
人民卫生出版社

中国医刊

CSTPCD
影响因子:1.14
ISSN:1008-1070
年,卷(期):2024.59(4)
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