Prognosis of patients with solitary hepatocellular carcinoma 2 cm or smaller underwent liver resection or radiofrequency ablation
Objective To analyzed the long-term outcome of patients with solitary hepatocellular carcinoma(HCC)≤2 cm after liver resection(LR)and radiofrequency ablation(RFA).Method Between 2004 to 2015,patients with solitary small HCC≤2 cm who received LR or RFA were identified from the Surveillance,Epidemiology,and End Results database(SEER).Propensity score matched analysis was used to evaluate the cancer-specific and overall survival rates of the two groups.Result After propensity score matched analysis,the RFA group had 216 cases and LR group had 216 cases.Before treatments,the clinical factors were similar between two groups.The 5-year cancer-specific survival rates(CSS)of RFA and LR were 57.2%and 72.8%,respectively(χ2=7.135,P=0.008).The 5-year overall survival rates(OS)were 47.6%and 64.5%for RFA and LR groups(χ2=8.822,P=0.003).Multivariate analyses revealed that the RFA treatment and unmarried status were independent prognostic factors of CSS and OS for solitary small HCC patients after LR and RFA.Age＜45 years old was associated with longer OS.Conclusion For single small HCC(≤2 cm),LR provided better CSS and OS than RFA.
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