Analysis of influencing factors on the completion of full course medication in gynecological malignant tumor patients undergoing first time chemotherapy
Objective To explore the influencing factors of patients with gynecological malignant tumors who undergo chemotherapy for the first time to complete the whole course of medication,so as to provide a basis for improving medication compliance and improving the chemotherapy drug management process of patients with gynecologic malignant tumors.Method Patients with gynecological malignant tumors who completed at least 3 courses of first chemotherapy treatment in Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University from August 2020 to July 2021 were selected,and the basic drug knowledge cognition,medication compliance and coping ability of chemotherapy adverse reactions during the whole course of chemotherapy were evaluated through the self-designed chemotherapy medication questionnaire,and the items with the highest and lowest scores in these three scales were collected.The Pearson correlation coefficient was used to analyze the relationship between basic drug knowledge cognition,medication compliance,and ability to cope with chemotherapy adverse reactions in patients with gynecological malignant tumors undergoing chemotherapy for the first time.Result Univariate analysis showed that different payment methods,chronic disease history,and frequency of medication after chemotherapy were the influencing factors of basic drug knowledge cognition score of patients undergoing chemotherapy for the first time,and the difference was statistically significant(P＜0.05).Occupation and economic source were the influencing factors of medication adherence score,and the difference was statistically significant(P＜0.05).Occupation,place of residence,payment method,and type of medication taken after chemotherapy were the influencing factors of the ability to cope with chemotherapy adverse reactions,and the difference was statistically significant(P＜0.05).The items with the highest scores of basic medication knowledge and cognition were"understand the usage of the drugs taken",the items with the lowest scores were"understand the treatment method after forgetting to take the medication".Patients had the highest medication adherence in terms of not increasing medication dosage on their own when they perceive their symptoms to worsen,the patients had the lowest medication adherence in terms of energy without forgetting to take medication.In the scores of coping ability to cope with adverse reactions of chemotherapy,the scores of"understanding the treatment of fever""understanding the treatment of constipation""understanding the treatment of diarrhea"ranked the top 3,and the scores of"understanding the risk of thrombocytopenia""understanding the precautions after thrombocytopenia""understanding the treatment of abnormal liver function after chemotherapy"ranked in the bottom 3.The results of Pearson correlation coefficient showed that the score of coping ability to cope with chemotherapy adverse reactions was positively correlated with the score of basic drug knowledge and medication compliance(P＜0.05).Conclusion Patients who used NCMS payment,had a history of chronic disease,and took drugs after chemotherapy with a frequency of＞3 times per day had a low level of knowledge and cognition of chemotherapy adjuvant drugs,patients who relied on pensions for a low level of medication compliance,and rural patients who used NCMS payment,and 5 or more types of drugs after chemotherapy had a low ability to cope with chemotherapy adverse reactions.Therefore,in the management of chemotherapy drugs,it is necessary to focus on education and intervention for these types of patients,improve their awareness of basic medication knowledge and medication compliance,and then improve their ability to cope with chemotherapy adverse reactions.
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