Analysis of clinical characteristics of infantile-onset inflammatory bowel disease
Objective To analyze the clinical and laboratory test of infantile-onset inflammatory bowel disease(IO-IBD).Method 27 cases with IO-IBD and 61 infants with food protein-induced proctocolitis(FPIP)were retrospectively analyzed,who were admitted to the Children's Hospital Affiliated to Capital Institute of Pediatrics from January 2018 to December 2022.The two groups were compared in terms of clinical manifestations and laboratory examinations.Logistic regression analysis was used to determine the risk factors of IO-IBD.Result There were no significant differences in gender,age,clinical manifestations and diarrhea frequency between the two groups.The BMI of IBD group was significantly lower than that of the control group.The time from onset to diagnosis in IBD group was significantly longer than that in the control group.In the detection of intestinal wall thickening and perianal lesions by intestinal ultrasound,the IBD group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The white blood cell count,platelet count,CRP,erythrocyte sedimentation rate,IL-6 and IL-10 in IBD group were significantly higher than those in FPIP group.The albumin of IBD group was significantly lower than that of FPIP group.Multivariate logistic regression analysis showed that the increase of peripheral white blood cells,CRP,IL-6 and albumin were the risk factors for IO-IBD(P＜0.05).Conclusion Infants with long-term diarrhea and bloody stool should pay attention to the possibility of IO-IBD,especially combined with malnutrition,intestinal wall thickening and perianal lesions.It is recommended to improve colonoscopy and genetic testing as soon as possible to confirm the diagnosis.WBC,CRP,serum IL-6 and albumin levels can be used to distinguish IO-IBD from FPIP.
Inflammatory bowel diseaseInfantFood protein-induced proctocolitisClinical features
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