Efficacy of doxofylline assisted non-invasive ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure
Objective To investigate the clinical effect of doxofylline assisted non-invasive ventilator in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure,and the influence on blood gas indexes,respiratory function,T helper 17(Th17)cells and regulatory T(Treg)cells.Method Sixty patients with AECOPD complicated with respiratory failure were admitted to the Affiliated Hospital of West Anhui Health Vocational College from January 2019 to December 2022.The subjects were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with non-invasive ventilator,while the observation group was treated with doxofylline on the above basis for 7 consecutive days.The clinical effect,blood gas indexes,respiratory function,levels of Th17 cells and Treg cells,and incidence of adverse reactions were compared between the groups.Result The total clinical response rate in observation group(93.33%)was higher than that in control group(70.00%)(P＜0.05).There was no significant difference in blood gas indexes[blood pH value,arterial partial pressure of oxygen(PaO2),and arterial partial pressure of carbon dioxide(PaCO2)]or pulmonary function indicators[forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1)and peak expiratory flow(PEF)]between the groups before treatment(P＞0.05).After treatment,there were increases in pH values,PaO2 and pulmonary function indicators in both groups,and these indicators in observation group were higher than those in control group.There were decreases in PaCO2 in both groups,and PaCO2 in observation group was lower than that in control group.The differences between groups were statistically significant(P＜0.05).There was no statistically significant difference in the levels of Th17 cells and Treg cells between the groups before treatment(P＞0.05).After treatment,there were decreases in Th17 cells levels in both groups,and the level in observation group was lower than that in control group.There were increases in Treg cells levels,and the level in observation group was higher than that in control group.The differences between groups were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Doxofylline assisted non-invasive ventilator was effective in the treatment of AECOPD complicated with respiratory failure,which could improve blood gas indexes,respiratory function,and regulate the levels of Th17 cells and Treg cells,with good safety.
Acute exacerbation of chronic obstructive pulmonary diseaseRespiratory failureDoxophyllineNon-invasive ventilatorBlood gas index
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