Effects of inflammation,oxidative stress and negative emotion on infection after enterostomy in rectal cancer patients
Objective To investigate the influence of inflammation,oxidative stress and negative emotion on infection after enterostomy in rectal cancer patients.Method Ninety-four patients with rectal cancer treated with colostomy in the First Affiliated Hospital of Xinjiang Medical University from June 2021 to March 2023 were enrolled in the study.They were divided into infected group(n=24)and uninfected group(n=70)according to postoperative infection.The differences of clinical general condition,inflammation related indexes[interleukin(IL)-2,IL-6,IL-8,procalcitonin(PCT)],oxidative stress related indexes[superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)]and emotion related indexes[social impact scale(SIS),self-rating depression scale(SDS),self-rating anxiety scale(SAS)]between the two groups were compared.The correlation of oxidative stress,inflammation and emotion with postoperative infection in patients with rectal cancer was analyzed,and the risk factors of infection were screened by multivariate regression analysis.Result The average levels of serum SOD and GSH-Px in infected patients were significantly lower,while the average levels of serum MDA,IL-2,IL-6,PCT,SIS score,SDS score and SAS score were significantly higher than the uninfected patients(P＜0.05).Spearman correlation analysis showed that serum MDA,IL-6,PCT,SIS score,SDS score and SAS score were positively correlated with postoperative infection in rectal cancer patients after enterostomy,while serum GSH-Px level was negatively correlated with postoperative infection(P＜0.05).High serum MDA,PCT and SAS scores were risk factors for postoperative infection,while high serum GSH-Px and SOD levels were protective factors for postoperative infection(P＜0.05).Conclusion The higher level of oxidative stress and inflammation after colostomy may be related to postoperative infection,and the serious negative emotion is also the risk factor of postoperative infection.For such patients,we should pay attention to the level of stress and emotional changes to reduce the risk of postoperative infection.
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