Relationship between serum NF-κB,TNF-α,MCP-1 and senile coronary heart disease complicated with frailty syndrome and construction of prediction model of related factors
Objective To analyze the relationship between serum nuclear factor-κB(NF-κB),tumor necrosis factor-α(TNF-α),monocyte chemokine-1(MCP-1)and senile coronary heart disease(CHD)complicated with frailty syndrome,and to construct the prediction model of related factors.Method Fifty cases of elderly patients with CHD complicated with asthenic syndrome received in Shanghai First People's Hospital Jiading Branch from March 2021 to March 2023 were selected as the observation group for retrospective study,another 50 cases of pure elderly patients with CHD received in Shanghai First People's Hospital Jiading Branch during the same period were selected as the control group,and 50 cases of healthy elderly patients receiving physical examination in Shanghai First People's Hospital Jiading Branch during the same period were selected as the healthy group.Serum NF-κB,TNF-α and MCP-1 were detected in all patients,and the level of NF-κB,TNF-α and MCP-1 and EFS scores were evaluated by Edmonton Frailty Scale(EFS).The levels of NF-κB,TNF-α and MCP-1 in the three groups were compared,and the levels of NF-κB,TNF-α and McP-1 in the groups with different frailty levels were compared.The correlation between serum NF-κB,TNF-α and MCP-1 and EFS scores was analyzed by Pearson,and the receiver operating curve(ROC)was plotted,and the area under the curve(AUC)was calculated,and the diagnostic efficacy of serum NF-κB,TNF-α and MCP-1 on asthenic syndrome was analyzed.The personal information of patients was collected by consulting medical records and consulting patients.The risk factors of elderly CHD complicated with asthenic syndrome were analyzed by univariate and multivariate logistic regression.A line graph prediction model was constructed by R software,and internal verification was conducted by Bootstrap method.Hosmer-Lemeshow was used for goodness of fit test.Result The levels of NF-κB,TNF-α,MCP-1 and EFS scores in observation group were higher than those in control group and healthy group(P＜0.05).The levels of NF-κB,TNF-α and MCP-1 in severe group were higher than those in moderate and mild groups(P＜0.05).Serum NF-κB,TNF-α and MCP-1 were positively correlated with EFS scores(P＜0.05,r=0.409,0.392,0.411).Age,depressive symptoms,anxiety symptoms,malnutrition,NYHA grade and physical activity were risk factors for CHD with fthenia syndrome in the elderly(P＜0.05).Hosmer-Lemeshow goodness of fit test(χ2=3.068 P=0.412),indicating good goodness of fit.C-index=0.912,indicating that the line graph was good at distinguishing CHD combined with frailty syndrome in the elderly.The AUC value was 0.915(95%CI 0.823-0.956),indicating that the prediction model had high discriminant ability and prediction value.Conclusion Excessive high expression of NF-κB,TNF-α and MCP-1 in serum of elderly CHD patients with asthenic syndrome is closely related to the severity of asthenic syndrome.Combined detection can improve the diagnostic efficiency of asthenic syndrome.The occurrence of asthenic syndrome is related to a variety of factors.Minimize the incidence of debilitating syndrome.
Nuclear factor-κBTumor necrosis factor-αMonocyte chemokine-1Coronary heart diseaseDebilitating syndromeRisk factorsPrediction model
万方数据
维普
