Effect of hyperbaric oxygen therapy on spinal cord injury and its influence on neuroelectrophysiology
Objective To investigate the efficacy of hyperbaric oxygen therapy for spinal cord injury and its effect on neuroelectrophysiology.Method From October 2019 to June 2022,104 spinal cord injury patients admitted to the Department of Spine Surgery,Second Hospital of Jilin University were selected and divided into a control group and an observation group using the random number grouping method,with 52 cases in each group.The control group received conventional treatment,and the observation group received hyperbaric oxygen therapy based on conventional treatment.The American Spinal Injury Association(ASIA)neurological function grades,motor nerve conduction velocity(MCV)and sensory nerve conduction velocity(SCV)of the median,ulnar,tibial and common peroneal nerves,and serum levels of interleukin(IL)-6,IL-10,IL-17 and high-sensitivity C-reactive protein(hs-CRP)were compared between the two groups before and after treatment.Result The differences in ASIA neurological function grades,MCV,SCV and serum IL-6,IL-10,IL-17 and hs-CRP levels were not statistically significant when comparing the two groups before treatment(P＞0.05).Compared with the pre-treatment,the ASIA nerve function grading of both groups improved significantly after treatment,and the observation group was significantly better than the control group;the MCV and SCV of the median nerve,ulnar nerve,tibial nerve,and common peroneal nerve increased significantly,and the observation group was significantly higher than the control group;and the levels of serum IL-6,IL-10,IL-17,and hs-CRP were all significantly lower,and the observation group was significantly lower than the control group,and the differences were statistically significant(P＜0.05).Conclusion Hyperbaric oxygen treatment of spinal cord injury can significantly improve nerve function,increase motor and sensory nerve conduction velocity,and reduce inflammatory response.
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