The effects of different doses of remimazolam on hemodynamic level and stress response in patients undergoing abdominal surgery under general anesthesia
Objective To investigate the effects of different doses of remimazolam on hemodynamic level and stress response in patients undergoing abdominal surgery under general anesthesia.Method A total of 120 abdominal surgery patients undergoing general anesthesia with tracheal intubation admitted to Handan Central Hospital and Handan Mingren Hospital from August 2019 to May 2021 were selected as the study objects.They were divided into group A,group B,group C and group D by random number table method,with 30 cases in each group.Group A was given 0.2 mg/kg remimazolam for anesthesia induction,and group B was given 0.3 mg/kg remimazolam for anesthesia induction,and group C was given 0.4 mg/kg remimazolam for anesthesia induction,and group D was given 2.0 mg/kg propofol for anesthesia induction.The sedation effect after anesthesia induction,the hemodynamic indexes(MAP,HR),stress response indexes(ACTH,NO)before and after surgery,and perioperative adverse reactions in the four groups were compared and analyzed.Result The sedation effective rates of patients in group B,group C and group D after anesthesia induction were higher than those in group A,with statistical significance(P＜0.05).There were no significant differences in the effective rates of sedation in group B,group C and group D after anesthesia induction(P＞0.05).2 days after surgery,MAP in group D was lower than that in group A,group B and group C,and HR in group D was lower than that in group A and group B,and ACTH and NO in group B were lower than those in group A and group D,with statistical significance(P＜0.05).The total incidence of perioperative adverse reactions in group D was higher than that in group A,group B and group C,with statistical significance(P＜0.05).There was no significant difference in the total incidence of perioperative adverse reactions in groups A,group B and group C(P＞0.05).Conclusion 0.3 mg/kg remimazolam anesthesia induction can significantly reduce the stress response of patients undergoing abdominal surgery under general anesthesia with tracheal intubation while maintaining the stable hemodynamic level,and has good sedation effect and safety,which is worthy of clinical application.
万方数据
维普
