Analysis of clinical efficacy of coenzyme Q10 combined with flunarizine in the treatment of migraine
Objective To explore the clinical efficacy of coenzyme Q10 combined with flunarizine in the treatment of migraine.Method A total of 104 migraine patients admitted to The Third Hospital of Mianyang in Sichuan Province from January to June 2023 were selected as the study objects.They were divided into control group and observation group by random number table method,with 52 cases in each group.The control group was treated with flunarizine,and the observation group was treated with coenzyme Q10 combined with flunarizine.Two groups were treated for 6 months.The clinical efficacy in the two groups after 6 months of treatment and the occurrence of adverse reactions between the two groups were compared and analyzed.Cerebral hemodynamic indexes(mean blood flow velocity of posterior cerebral artery,mean blood flow velocity of middle cerebral artery,mean blood flow velocity of anterior cerebral artery),stress response indexes(PON-1,ox-LDL,ArE),migraine symptoms(migraine attack duration,severity of pain,migraine attack frequency)in the two groups were compared and analyzed before and after treatment.NRS was used to assess the degree of migraine pain in two groups.Result After 6 months of treatment,the total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P＞0.05).After 6 months of treatment,the mean blood flow velocity of the middle cerebral artery,the mean blood flow velocity of the anterior cerebral artery,the mean blood flow velocity of the posterior cerebral artery,ox-LDL,migraine attack frequency and migraine attack duration in the two groups were all decreased or shortened compared with before treatment,and the observation group was lower or shorter than the control group,and the differences were statistically significant(P＜0.05).After 6 months of treatment,PON-1 and ArE in two groups were higher than before treatment,and the observation group was higher than the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in NRS scores between the two groups before treatment and 6 months after treatment(P＞0.05).Conclusion The combination of coenzyme Q10 and flunarizine in the treatment of migraine has a significant clinical effect,and can effectively improve the cerebral hemodynamics of patients,oxidative stress state,with good safety.
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