Predictive value of preoperative peripheral blood indicators and clinical pathological parameters for lymph node metastasis in patients with endometrial carcinoma
Objective To analyze the factors of lymph node metastasis(LNM)in endometrial carcinoma(EC)and to explore the predictive value of preoperative peripheral blood index and clinicopathological parameters for LNM in EC patients.Method A retrospective analysis was performed on 183 EC patients admitted to the First Clinical Medical College of Shanxi Medical University from January 2018 to July 2023.Of the 145 patients who underwent LNM,129 had no LNM(no LNM group)and 16(11.03%)had LNM(LNM group).Univariate analysis and multivariate logistic regression analysis were used to investigate the risk factors of LNM in EC patients.The predictive value of carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)levels for LNM in EC patients was analyzed by receiver operating characteristic(ROC)curve.Result Unifactor analysis showed that LNM in EC patients was correlated with pathological type,FIGO stage,depth of myometrium invasion,tumor diameter,attachment involvement,lymph vascular space invasion,cervical space invasion,preoperative peripheral blood CA125,carbohydrate antigen 19-9,human epididymis protein 4,and CEA levels(P＜0.05).Multivariate logistic regression analysis showed that pathological types of non-endometrioid carcinoma,lymphatic space infiltration,preoperative peripheral blood CA125 and CEA were independent influencing factors for LNM in EC patients(P＜0.05).ROC curve analysis results showed that preoperative peripheral blood CA125,CEA alone had certain predictive value for LNM in EC patients(P＜0.05).Conclusion Patients with EC have a high risk of LNM,which might be related to the patients'type of non-endometrioid carcinoma,lymphatic space infiltration,preoperative peripheral blood CA125 and CEA levels.The individual and combined detection of CA125 and CEA have great value in predicting LNM status in EC patients,which is helpful for individualized treatment.
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