Effects of Shensong Yangxin capsule combined with sacubitril valsartan sodium tablet on ventricular remodeling,cardiac function grading and inflammatory factors in chronic heart failure combined with ventricular arrhythmia
Objective To observe clinical curative effect of Shensong Yangxin capsule combined with sacubitril valsartan sodium tablet and its influences on ventricular remodeling and inflammatory factors in chronic heart failure(CHF)combined with ventricular arrhythmia(VA).Method The patients with CHF and VA in the 901th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army were enrolled as the research objects between June 2021 and January 2024.Among them,60 cases treated with sacubitril valsartan sodium tablets were included into monotherapy group,while 64 cases treated with Shensong Yangxin capsules combined with sacubitril valsartan sodium tables were included into combined medication group according to the principle of inter-group baseline matching.The cardiac function grading,ventricular remodeling[left ventricular posterior wall thickness(LVPWT),interventricular septal thickness(IVST),left ventricular mass index(LVMI)],heart rate variability[standard deviation of 24 h normal R-R interval(SDNN),mean of the standard deviation of the normal R-R interval of 5 min continuous 24 h(SDNN index),standard deviation of the normal R-R interval of 5min continuous 24 h(SDANN index),root mean square value of adjacent normal R-R interval(rMSSD)],electrocardiogram parameters[PR interval,QTc interval,24h QT variability(24hQTV)],inflammatory factors[tumor necrosis factor α(TNF-α),interleukin-1β(IL-1β),hypersensitive C-reactive protein(hs-CRP)]and the incidence of adverse reactions were compared between the two groups.Result After treatment,proportion of grade-IV cardiac function was significantly decreased in both groups,and which was lower in combined medication group(P＜0.05).After treatment,LVPWT,IVST and LVMI were decreased in both groups,which were lower in combined medication group than monotherapy group(P＜0.05).After treatment,levels of TNF-α,IL-1β and hs-CRP were decreased in both groups,which were lower in combined medication group than monotherapy group(P＜0.05).Before treatment,there was no significant difference in heart rate variability indexes between the two groups(P＞0.05).After treatment,SDNN,SDNN index,SDANN index and rMSSD were increased in both groups,which were higher in combined medication group than monotherapy group(P＜0.05).After treatment,QTc interval was decreased in both groups,which was lower in combined medication group than monotherapy group(P＜0.05),while PR interval and 24 hQTV were increased,which were higher in combined medication group than monotherapy group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shensong Yangxin capsule combined with sacubitril valsartan sodium tablet is beneficial to improve cardiac function grading,inhibit expressions of inflammatory factors,relieve arrhythmia and improve ventricular remodeling in patients with CHF and VA.
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