Impact of postoperative hepatic artery chemoembolization on the prognosis of patients with primary hepatocellular carcinoma complicated by type Ⅰ portal vein tumor thrombus
Objective To investigate the impact of postoperative transcatheter arterial chemoembolization(TACE)on the prognosis of patients with primary hepatocellular carcinoma(HCC)complicated by portal vein type I cancer thrombus.Method A retrospective study included 45 patients who underwent surgical resection for HCC with portal vein type I cancer thrombus at Beijing Haidian Hospital and the First Affiliated Hospital of Guangxi Medical University from 2016 to 2020.Among them,28 patients received TACE and were assigned to the observation group,while 17 patients did not receive TACE and were assigned to the control group.Kaplan-Meier curves were used to analyze survival between the two groups,and univariate log-rank test and multivariate Cox regression analysis were employed to identify independent risk factors affecting patient survival time.Result The univariate log-rank test indicated that age,body mass index,preoperative alpha-fetoprotein level,liver cirrhosis,tumor diameter,Barcelona Clinic Liver Cancer(BCLC)stage,and postoperative TACE were factors influencing the survival time of patients with HCC and portal vein type I cancer thrombus(P＜0.05).Multivariate Cox regression analysis revealed that preoperative alpha-fetoprotein level was an independent risk factor(P＜0.05),while body mass index and postoperative TACE were independent protective factors(P＜0.05).Conclusion For patients with HCC complicated by portal vein type I cancer thrombus,postoperative TACE can prolong survival time and improve prognosis.
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