Effects of edaravone combined with nimodipine on vascular endothelial function and cerebral artery flow velocity in patients with cerebral vasospasm after cerebral aneurysm surgery
Objective To explore the effects of edaravone combined with nimodipine on vascular endothelial function and cerebral artery flow velocity in patients with cerebral vasospasm after cerebral aneurysm surgery.Method 80 patients with cerebral vasospasm after cerebral aneurysm surgery in 363 Hospital in Sichuan Province from May 2021 to May 2023 were selected as the study objects.They were divided into single drug group(nimodipine treatment,40 cases)and combination group(edaravone combined with nimodipine treatment,40 cases)by random number table method.Two groups were treated continuously for two weeks.The clinical efficacy in the two groups after two weeks was compared and analyzed.Neurological impairment(NIHSS score),consciousness disorder severity(GCS score),activity of daily living(BI score),cerebral artery blood flow velocity(MPV),average blood flow velocity(Vm),vascular endothelial function(ET-1,NO)before and after treatment,and the occurrence of adverse reactions during treatment in the two groups were compared and analyzed.Result After two weeks of treatment,the total clinical effective rate in the combination group was higher than that in the single drug group,with statistical significance(P＜0.05).Compared with before treatment,NIHSS score and ET-1 in two groups after two weeks of treatment were decreased,and combination group was lower than single drug group,with statistical significance(P＜0.05),and GCS score,BI score,MPV of middle cerebral artery,Vm of middle cerebral artery,NO were all increased,and combination group was higher than single drug group,with statistical significance(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The clinical efficacy of edaravone combined with nimodipine in the treatment of patients with cerebral vasospasm after cerebral aneurysm surgery is significant,which can improve the vascular endothelial function and cerebral artery flow velocity,with good safety.
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