Relationship between OPG/RANKL,SENP-1,Lp-PLA2 and the severity of obstructive OSAHS and its predictive value for CVE were analyzed
Objective To analyze the relationship between osteoprotegerin(OPG)/receptor activator of nuclear factor-кB ligand(RANKL),small ubiquitin-like modifier protein-specific protease 1(SENP-1),lipoprotein-associated phospholipase A2(Lp-PLA2)and the severity of obstructive sleep apnea hypopnea syndrome(OSAHS)and its value in predicting cardiovascular events(CVE).Method A prospective study was conducted to select 120 patients with OSAHS who were treated in the hospital from September 2021 to September 2022.The patient's condition was evaluated according to the'Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea Hypopnea Syndrome(Basic Edition)',and the patients were divided into mild group,moderate group and severe group according to the condition.The baseline data of the patients were counted and compared.Multivariate logistic regression was used to analyze the relationship between OPG/RANKL,SENP-1,Lp-PLA2 and the severity of obstructive OSAHS.The patients were followed up for 1 year,and the occurrence of cardiovascular events(CVE)during the follow-up period was recorded.The patients with CVE were included in the CVE group,and the patients without CVE were included in the non-CVE group.The levels of OPG/RANKL,SENP-1 and Lp-PLA2 at admission were compared between the two groups.Receiver operating characteristic curve(ROC)was used to evaluate the levels of OPG/RANKL,SENP-1 and Lp-PLA2 to predict the risk of CVE in OSAHS patients.Result The body mass index,neck circumference,waist circumference,hip circumference,RANK,SENP-1 and Lp-PLA2 in the severe group were higher than those in the moderate group and the mild group,and the moderate group was higher than the mild group(OR＜1,P＜0.05).The high levels of OPG and OPG/RANKL were protective factors for the aggravation of OSAHS patients(OR＜1,P＜0.05).OPG and OPG/RANKL in CVE group were lower than those in non-CVE group,while RANKL,SENP-1 and Lp-PLA2 were higher than those in non-CVE group(P＜0.05).The results of ROC curve showed that the AUC of OPG/RANKL,SENP-1,Lp-PLA2 and combined detection of CVE in OSAHS patients were all＞0.70,which had good predictive efficacy,and the combined detection had higher predictive efficacy.Conclusion The levels of OPG/RANKL,SENP-1 and Lp-PLA2 are closely related to the severity of OSAHS patients,and the three can also effectively predict the risk of CVE in OSAHS patients.
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