Relationship between serum soluble growth stimulation gene 2 protein and hypoxia inducible factor-1α and prognosis of non-ST segment elevation myocardial infarction complicated with chronic heart failure
Objective To investigate the relationship between serum soluble growth stimulation gene 2 protein (sST2),hypoxia inducible factor (HIF-1α) and prognosis of non-ST elevation myocardial infarction (NSTEMI) complicated with chronic heart failure. Method 167 NSTEMI patients with chronic heart failure were selected from 3201 Hospital of Shaanxi Province from June 2020 to May 2023. The patients were followed up for 1 year and divided into death group (n=43) and survival group (n=124). General data and serum sST2 and HIF-1α levels were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors of death in NSTEMI patients with chronic heart failure. The predictive value of the two serum indicators in NSTEMI patients with chronic heart failure was analyzed by receiver operating characteristic (ROC) curve. Result The proportion of grade Ⅲ to Ⅳ,white blood cell count (WBC),hypersensitive C-reactive protein (hs-CRP),N-terminal B-type natriuretic peptide precursor (NT-proBNP),sST2 and HIF-1α levels in the death group were higher than those in the survival group,while the left ventricular ejection fraction (LVEF) was lower than that in the survival group,with statistical significance (P<0.05). Multivariate logistic regression model showed that cardiac function grade Ⅲ～Ⅳ,high level of NT-proBNP,sST2 and HIF-1αwere independent risk factors for death in NSTEMI patients complicated with chronic heart failure (P<0.05). ROC curve showed that the AUC (95％CI) of serum sST2 and HIF-1α alone in predicting death of NSTEMI patients with chronic heart failure were 0.734 (0.649～0.812) and 0.765 (0.681～0.847). The combined forecast AUC (95％CI) is 0.889 (0.792～0.938). The combined diagnosis model was established based on the risk factors of Logistic regression analysis model. The AUC (95％CI) predicted by the combined model was 0.920 (0.865～0.958),and the prediction efficiency of the combined model was higher than that of serum sST2 and HIF-1α alone or combined. Conclusion The expression of serum sST2 and HIF-1α is abnormally elevated in NSTEMI patients with chronic heart failure,which can be used as an important reference for predicting the prognosis of patients.
万方数据
维普
