中国医科大学学报2024,Vol.53Issue(3) :266-270.DOI:10.12007/j.issn.0258-4646.2024.03.014

某医院近10年大肠埃希菌分离率和耐药率的变迁情况

Changes in the isolation and drug resistance rate of Escherichia coli in a hospital over the past 10 years

郭丽洁 李富顺 陈静静 王齐晖 褚云卓
中国医科大学学报2024,Vol.53Issue(3) :266-270.DOI:10.12007/j.issn.0258-4646.2024.03.014

某医院近10年大肠埃希菌分离率和耐药率的变迁情况

Changes in the isolation and drug resistance rate of Escherichia coli in a hospital over the past 10 years

郭丽洁 1李富顺 1陈静静 1王齐晖 1褚云卓1
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作者信息

  • 1. 中国医科大学附属第一医院检验科,沈阳 110001
  • 折叠

摘要

目的 总结近10年中国医科大学附属第一医院大肠埃希菌的分离率和耐药率,为临床抗感染经验治疗提供依据.方法 数据来自2013年至2022年间从中国医科大学附属第一医院就诊患者中分离的大肠埃希菌,使用VITEK 2和VITEK MS进行菌种鉴定,使用VITEK2和KB法进行药物敏感性试验,采用WHONET 5.6软件进行分析.结果 2013年至2022年共分离6 845株菌株,其中80.5%来自住院患者,19.5%来自门诊和急诊患者.常见标本类型为尿液(57.8%)、血液(15.0%)、分泌物(9.2%)、引流液(8.1%).大肠埃希菌超广谱β-内酰胺酶(ESBL)分离率为57.2%(54.3%~61.5%).大肠埃希菌对碳青霉烯类抗菌药物的耐药率较低,仅为1.2%(0.2%~2.6%).结论 大肠埃希菌仍是临床感染的重要病原菌,对多种抗菌药物存在不同程度的耐药,且耐药率有上升趋势,临床医师应给予足够的关注.

Abstract

Objective To summarize the isolation and drug resistance rate of Escherichia coliin The First Hospital of China Medical University over the past 10 years,in order to provide evidence for the efficacies of clinical anti-infection treatments.Methods The data was collected from Escherichia coli isolated from patients treated at The First Hospital of China Medical University between 2013 and 2022.VITEK 2 and VITEK MS were used for bacterial identification,VITEK2 and KB method were used for drug sensi-tivity testing,and WHONET 5.6 software was used for analysis.Results From 2013 to 2022,6 845 strains were isolated,including 80.5%from inpatients and 19.5%from emergency and outpatients.The specimens were most commonly found in the urine(57.8%),blood(15.0%),secretions(9.2%),and drainage fluid(8.1%).The isolation rate of extended-spectrumβ-lactamase(ESBL)producing Escherichia coli was 57.2%(54.3%to 61.5%).The drug resistance rate of Escherichia coli to carbapenems was low,at only 1.2%(0.2%to 2.6%).Conclusion Escherichia coli remains an important pathogen in clinical infections,with varying degrees of resist-ance to multiple antibiotics,and the resistance rate is increasing.Clinical physicians should pay sufficient attention to this issue.

关键词

细菌耐药监测/药物敏感性/大肠埃希菌

Key words

bacterial drug resistance monitoring/drug sensitivity test/Escherichia coli

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出版年

2024
中国医科大学学报
中国医科大学

中国医科大学学报

CSTPCD北大核心
影响因子:1.421
ISSN:0258-4646
被引量1
参考文献量11
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