Relationship between serum uric acid levels in normotensive pregnant women at full-term of pregnancy and birth weight of newborns
Objective To investigate the relationship between serum uric acid levels of full-term pregnant women with normal blood pressure and the birth weight of their newborns.Methods A total of 1200 pregnant women in the obstetrics ward of Shengjing Hospital of China Medical University were randomly selected by stratification for the study from January 2012 to December 2022.These women had full-term delive-ries and a normal blood pressure.According to the weight of neonates at delivery,they were divided into groups as follows:appropriate for gestational age(AGA,n=600),large for gestational age(LGA,n=300),and small for gestational age(SGA,n=300).Clinical data of the patients was collected for a retrospective study.Nonparametric tests were used to compare the differences in each group,and logistic regression was used to analyze the factors influencing neonatal birth weight.Results The maternal serum uric acid values in the LGA and SGA groups were 336(269-388)μmol/L and 377(297-431)μmol/L,respectively-much higher than that of the AGA group[288(243-350)μmol/L,P<0.001].Multivariate logistic regression analysis showed that the risk of occurrence for LGA(for every 10 μmol/L increase in the blood uric acid level of pregnant women,the adjusted OR=1.040,95%CI:1.020-1.060)and SGA(for every 10 μmol/L increase,the adjusted OR=1.072,95%CI:1.049-1.095)increased with the level of uric acid in the patients.The birth weight percentile of neonates in the LGA group was positively correlated with uric acid levels(r=0.108,P<0.05),while in the SGA group it was negatively correlated with uric acid levels(r=-0.224,P<0.01).Restrictive cubic spline regression analysis showed that the rela-tionship between maternal uric acid levels and newborn birth weight was similar to a"U"shape.When newborn birth weight was around 3000 g,maternal uric acid level was the lowest.Conclusion Serum uric acid level of full-term pregnant women with normal blood pres-sure is an independent risk factor for neonatal birth weight.Serum uric acid level of full-term pregnant women with normal blood pressure is closely associated to neonatal birth weight,and shows a positive correlation in the LGA group and negative correlation in the SGA group.
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