跨膜蛋白16A及其抑制剂的研究进展
Research progress on transmembrane protein 16A and its inhibitors
狄鹏飞 1陈思予 2杨鸿鸣 1肖庆桓 3雒舒雅3
作者信息
- 1. 中国医科大学第一临床学院
- 2. 中国医科大学中英联合学院
- 3. 中国医科大学药学院药学离子通道研究室,沈阳 110122
- 折叠
摘要
跨膜蛋白16A(TMEM16A)是一种具有电压依赖性的钙激活氯离子通道,广泛表达于癌细胞中.在多种癌症中,TMEM16A不仅可以调控癌细胞的增殖、侵袭和转移,还与癌症治疗的预后相关.近年来,TMEM16A以及TMEM16A抑制剂在癌症领域的相关研究不断深入.本文总结了近10年来的相关研究,旨在为今后TMEM16A抑制剂在癌症治疗中的临床应用提供新的治疗策略.
Abstract
Transmembrane protein 16A(TMEM16A)is a voltage-dependent calcium-activated chloride channel that is widely expressed in cancer cells.In a variety of cancer types,TMEM16A regulates the proliferation,invasion,and metastasis of cancer cells and is corre-lated with the prognosis of cancer under treatment.In recent years,TMEM16A and its inhibitors have been intensively studied in cancer treatment.This review summarizes relevant studies conducted over the past 10 years,aiming to provide a novel therapeutic strategy for the clinical application of TMEM16A inhibitors in future cancer therapy.
关键词
跨膜蛋白16A/钙激活氯离子通道/抑制剂/癌症/研究进展Key words
transmembrane protein 16A/calcium-activated chloride channel/inhibitor/cancer/research progress引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据