鸢尾素在糖脂代谢及肥胖中的作用
Role of irisin in improving glucose levels,lipid metabolism,and obesity
张艺萍 1丁璟 1张祎 1姜禹彤 1邱吉巍 1魏迎亮2
作者信息
- 1. 中国医科大学 第二临床学院,沈阳 110122
- 2. 中国医科大学 附属盛京医院骨科,沈阳 110022
- 折叠
摘要
肥胖作为一种代谢性疾病,能够增加人体多种慢性代谢性疾病的患病风险,已引起世界范围内的广泛关注.运动是控制和治疗肥胖的重要手段.鸢尾素是2012年被发现并报道的一种肌细胞因子,受运动调控,参与脂肪组织的褐变.鸢尾素通过影响脂代谢来改善肥胖,可以诱导白色脂肪棕色化,促进葡萄糖稳态,还可以抵抗炎症、氧化应激等因素对脂肪细胞的损伤,抑制胰岛素抵抗,改善糖脂代谢及肥胖.本文综述了鸢尾素在糖脂代谢及肥胖中的作用,以及运动对鸢尾素的调节机制,并对未来研究提出展望.
Abstract
As a metabolic disease,obesity increases the risk of many chronic metabolic diseases;in fact,it is an epidemic in the 21st cen-tury.Exercise is an important means of controlling and treating obesity.Irisin,a myocyte cytokine,was discovered and reported in 2012;it is regulated by exercise and involved in the browning of adipose tissue.A recent discovery is irisin's ability to improve obesity,which is embodied in its effect on glucose and lipid metabolism.Irisin can induce the browning of white fat;promote glucose homeostasis;resist the damage of fat cells caused by inflammation,oxidative stress,and other factors;inhibit insulin resistance;and improve glucose,lipid metabolism,and obesity.This review addresses the role of irisin in improving glucose levels,lipid metabolism,and obesity,as well its role in regulating exercise.Further,the prospect of future research is discussed.
关键词
运动/鸢尾素/糖脂代谢/白色脂肪棕色化/胰岛素抵抗Key words
exercise/irisin/glucose and lipid metabolism/browning of white fat/insulin resistance引用本文复制引用
基金项目
国家自然科学基金青年基金(31900847)
出版年
2024
国家科技期刊平台
NSTL
万方数据