Clinical benefit analysis of external application of tacrolimus ointment assisted by 308 nm ultraviolet light irradiation in the treatment of vitiligo
Objective To explore the application effect of external application of tacrolimus ointment combined with 308 nm ultraviolet light irradiation in the treatment of vitiligo patients.Method A total of 120 cases were selected for this study,all of whom were vitiligo patients admitted to our hospital between March 2021 and March 2023.They were screened for inclusion and exclusion criteria and divided into a control group and an observation group based on different treatment methods.The number of cases was equal,with 60 cases in both groups.The former received simple 308 nm excimer laser treatment,while the latter received treatment with tacrolimus ointment in addition to the former,both of which were treated for 3 months and followed up for 3 months.Compare two sets of relevant indicators.Results After comparing various data between the control group and the observation group,the results showed that the clinical total effective rate of the latter after receiving treatment was higher than that of the former;After treatment,the CD4+,CD4+/CD8+ levels,and DLQI scores of both groups were higher than before treatment.The intergroup comparison showed that the latter was higher,and the CD8+ level was lower than before treatment.The intergroup comparison showed that the latter was lower,and the white spot area was smaller than before treatment.The intergroup comparison showed that the latter was smaller,and after analysis by specific calculation software,the data difference was significant(P<0.05);There was no significant difference in adverse reactions and recurrence frequency between the two during follow-up(P>0.05).Conclusion:Topical application of tacrolimus ointment combined with 308 nm ultraviolet light irradiation can significantly improve the immune function of patients with vitiligo,reduce their white spot area,and improve their quality of life.It has high safety and definite therapeutic effect.
VitiligoTacrolimus ointment308 nm ultraviolet light irradiationImmune functionWhite spot are
万方数据
维普
