Meta-analysis of the efficacy and safety of platelet-rich plasma in the treatment of burn wounds
Objective To systematically evaluate the effect of platelet-rich plasma on burn wound healing through meta-analysis.Methods The Chinese and foreign databases such as Wanfang,CNKI,VIP,PubMed,Embase,Cochrane Library,Web of Science,etc.were searched by computer,and the search terms included"platelet-rich plasma","burn","burn wound",etc.in Chinese,and"platelet rich plasma","burn","burn wound",etc.in English.The clinical trial articles on the use of platelet-rich plasma in the treatment of burn wounds were searched from the establishment of the database to January 31,2024,and the included studies were checked for duplication,screened,quality evaluation and data extracted according to the inclusion and exclusion criteria,and meta-analysis was performed using Review Manager 5.4.1 software.Results A total of 28 articles and 2279 patients were included,and the meta-analysis of the outcome measures showed that the wound healing time[MD=-4.83,95%CI(-5.65,-4.02),P<0.00001],positive rate of wound bacterial culture[OR=0.42,95%CI(0.42,0.75),P=0.003],the number of wet gauze layers[MD=-5.09,95%CI(-6.42,-3.77),P<0.00001]and the VSS score after 1 year[MD=-0.77,95%CI(-1.00,-0.55),P<0.00001]in the experimental group were lower than those in the control group.The effective rate of treatment[OR=6.03,95%CI(3.33,10.92),P<0.00001]and the wound healing rate of the experimental group at the 1st[MD=8.43,95%CI(7.20,9.66),P<0.00001],2nd[MD=13.64,95%CI(8.73,18.56),P<0.00001]and 3rd[MD=15.84,95%CI(15.05,16.62),P<0.00001]weeks were higher than those in the control group.There was no significant difference in graft take rate[MD=24.37,95%CI(-19.10,67.84),P=0.27]or incidence of allergic reactions[OR=0.54,95%CI(-0.18,1.65),P=0.28].Conclusion Platelet-rich plasma can promote wound healing,improve the effective rate and wound healing rate,reduce the exudation and positive rate of wound bacterial culture,and have a better long-term VSS score in the treatment of burn wounds.There was no significant effect on graft adhesion rate and incidence of allergic reactions.
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