Study on the differences in efficacy of various combinations of surgical resection,hormone injection,radiotherapy and chemotherapy in keloid scars
Objective To assess the effectiveness of various therapeutic strategies,including surgical excision,hormonal therapy,radiation treatment,and chemical therapy,in individuals afflicted with keloid lesions.Methods 120 patients with scar tissue who visited our hospital from October 2021 to October 2023 were selected and divided into surgery+hormone injection group,surgery+radiation group,hormone injection+radiation group,surgery+hormone injection+radiation group,and surgery+hormone injection+radiation group according to the treatment method,with 30 cases in each group.The total effective rate,incidence of adverse reactions,recurrence rate,and changes in quality of life of each group of patients were evaluated.Results The group receiving a combination of surgical removal,hormonal injections,and radiation therapy exhibited the highest rate of effectiveness,succeeded by the group treated with surgery and hormone therapy,and then the group treated with surgery and radiation therapy.The group treated with hormone injections and radiation therapy had the lowest rate of effectiveness.The differences in effectiveness between the combined treatment group,the surgery and hormone therapy group,and the surgery and radiation therapy group were not statistically significant(P>0.05),yet these three groups showed a significant difference when compared to the hormone injection and radiation therapy group(P<0.05).The incidence of adverse reactions was least in the group treated with surgery and hormone injections(3.33%),and most prevalent in the group treated with hormone injections and radiation therapy(33.33%),with the disparity being statistically significant(P<0.05).The recurrence rate was lowest in the group treated with surgery,hormone injections,and radiation therapy(3.33%),while the highest recurrence was observed in the group treated with hormone injections and radiation therapy(30%),marking a statistically significant difference(P<0.05).The highest quality of life scores were recorded in the group treated with surgery,hormone injections,and radiation therapy,whereas the lowest scores were noted in the group treated with hormone injections and radiation therapy(P<0.05).Conclusion The therapeutic regimen combining surgical intervention,hormonal therapy,and radiation treatment yields the most favorable outcomes,with the minimal incidence of side effects and recurrences,and the smallest influence on patients'life quality.The efficacy of the dual approach of surgery plus hormone therapy is comparable to that of surgery plus radiation therapy,whereas the efficacy of hormone therapy in conjunction with radiation therapy is comparatively suboptimal.
万方数据
维普
