Analysis of the efficacy and safety of compound betamethasone combined with ultrapulse fractional CO2 laser in the treatment of hypertrophic scars after burns
Objective To analyze the effect and safety of compound betamethasone combined with Ultrapulse fractional CO2 laser(UFCL)in the treatment of hypertrophic scar(HS)after burn.Methods The data of 80 patients with HS after burn in our hospital from September 2022 to September 2023 were retrospectively analyzed.According to different treatment schemes,40 patients treated with UFCL were included in the control group,and 40 patients treated with compound betamethasone+UFCL were included in the observation group.The clinical efficacy,Vancouver Scar Scale(VSS)score,skin barrier function(epidermal water loss,stratum corneum water content,pH value),and levels of serum tumor necrosis factor-α(TNF-α),Granulated protein precursor(PGRN),transforming growth factor-β1(TGF-β1)and safety were compared between the two groups.Results The total effective rate of the observation group was 92.50%(37/40),which was higher than 75.00%(30/40)of the control group(P<0.05);after treatment,the color,vascular distribution,softness,thickness score and VSS total score of the observation group were lower than those of the control group(P<0.05);after treatment,the water content of stratum corneum in the observation group was higher than that in the control group,TNF-α,PGRN,TGF-β1,water loss and pH value of the control group were lower than those of the control group(P<0.05);the incidence of adverse reactions in the observation group was 12.50%(5/40)and 7.50%(3/40)in the control group,with no significant difference(P>0.05).Conclusion Compound betamethasone combined with UFCL is effective in the treatment of HS after burn,which can inhibit the proliferation of fibrous tissue,reduce the degree of scar,improve the skin barrier function,and has high safety.
Hypertrophic scarCompound betamethasoneUltrapulse fractional CO2 laser(UFCL)Vancouver Scar scoreSecurity
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维普
