Efficacy Observation of Microneedle-Assisted Minoxidil Treatment for Androgenetic Alopecia with Damp-Heat and Blood Stasis Pattern
Objective To observe the efficacy of microneedle-assisted minoxidil delivery in the treatment of androgenetic alopecia.Methods Eighty-six patients were randomly divided into three groups:29 cases in the minoxidil group,28 cases in the plum-blossom needle group,and 29 cases in the microneedle group.All three groups used topical minoxidil.The plum-blossom needle group used plum-blossom needles to deliver minoxidil,while the microneedle group used microneedles to deliver minoxidil.The efficacy of the treatments was observed after 12 weeks.Results(1)After treatment,there was a significant difference in DLQI among the three groups(P<0.05).(2)ptom scores:There was a significant difference between the microneedle group and the minoxidil group(P<0.05),a moderate difference between the microneedle group and the plum-blossom needle group(P>0.05,Cohen's d=0.551).(3)hair growth:There was a significant difference in new hair growth between the micronele group and the minoxidil group,as well as between the minoxidil group and the plum-blossom needle group after treatment(P<0.05).(4)There was a significant difference in the number of hair loss between the microneedle group and the minoxidil group,as well as between the microneedle group and the plum-blossom needle group after treatment(P<0.05).(5)Effective rate:Microneedle group 100%,plum-blossom needle group 96.42%,minoxidil group 93.10%;(6)Satisfaction rate:Microneed group 100%,plum-blossom needle group 92.85%,minoxidil group 86.21%,with significant intergroup differences(P>0.05).Conclusion(1)Patients in the microneedle group showed better improvement in DLQI and symptom scores compared to the plum-blossom needle-assisted minoxidil delivery and minoxidil-only topical application;(2)Transdermal delivery of minoxid was more effective in promoting new hair growth compared to topical minoxidil alone;(3)Microneedle-assisted minoxidil delivery was more advantageous in reducing the quantity of hair loss compared to plum-blossom needle-assisted minoxidil delivery and minoxidil-only topical application.It can be inferred that the real-world efficacy of microneedle-assisted topical minoxidil treatment for AGA in a large sample is better than that of plum-blossom needle-assisted minoxidil delivery and minoxidil-only topical application.The treatment method of microneedle-assisted delivery of the hair growth drug minoxidil is worthy of clinical promotion and application.
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