Study on skin characteristics and patch test of sensitive skin population in Chongqing
Objective To analysis the skin characteristics and cosmetics related allergic factors of sensitive skin populations in Chongqing area and evaluate the differences in patch test results between the SS population and the normal population,in order to provide guidance for local cosmetic adverse reaction monitoring and risk assessment.Methods Seventy-one volunteers who are positive for lactate stimulation test(LAST)and clinically evaluated as SS as the test group,70 normal individuals with LAST negative as the control group,improveing subject self-evaluation,physician clinical evaluation,non-invasive skin physiological index measurement(including skin moisture content,trans epidermal water loss,skin hemoglobin content,skin oil contentand and skin pH),and human skin closed patch test respectively,results were conducted and analyzed after the experiment.Results The lactate stinging score and overall feeling rating in the test group were higher than those in the control group,and the differences are statistically significant,the scores of the two groups were(3.54±0.65)and(2.71±0.87)respectively(P<0.05).The cosmetic ingredient patch test in the test group showed that 57 cases(82.61％)were positive reactions for≥1 component,while 44 cases(63.77％)positive reactions for≥3 components,the allergens include lauryl glucoside(36.23％),lauryl gallate(36.23％),octyl gallate(26.09％),nickel sulfate(23.19％),sunyl glucoside(21.74％),orbitan oleate(20.29％)and methyl dibromoglutaryl cyanide(20.29％).The cosmetic ingredient patch test in the control group showed that 41cases(58.75％)were positive reactions for≥1 component,while 1 6 cases(22.86％)positive reactions for≥3 components,the allergens include lauryl gallate(20.29％),octyl gallate(18.57％),laurylglucoside(18.57％),sorbitol sesquioleate(15.71％),sorbitan oleate(11.43％),thiomersal(8.57％)and nickel sulfate(8.57).The scores of itching,stinging,burning,erythema and scaling in the control group were significantly lower than those in the experimental group(P<0.005;there were significant differences in oil conten,water content,TEWL,erythema indexand skin pH between the two groups(P<0.05),indicating impaired skin barrier function in the experimental group.Conclusions Sensitive skin populations in Chongqing have varying degrees of skin barrier damage,accompanied by conscious symptoms and objective signs,lactate stinging score significantly increases,allergies to various cosmetic ingredients,such as lauryl glucoside,lauryl gallat,octyl gallate,nickel sulfate and so on.
sensitive skinskin characteristicsskin barrierpatch test
万方数据
维普
