Clinical efficacy of precision light combined with isotretinoin in the treatment of rosacea and its influence on skin lesion score and adverse reactions
Objective To explore the application effect of precision light combined with isotretinoin in rosacea,and analyze its impact on the patient's skin lesion score and adverse reactions.Methods A total of 60 patients with moderate to severe rosacea admitted to the Department of laser cosmetology of Henan Jingcheng skin traditional Chinese medicine hospital from May 2020 to may 2021 were selected and divided into three groups,A,B and C,with 20 cases in each group.Patients in group A were treated with oral isotretinoin,patients in group B were treated with precision light therapy(DPL),and patients in group C were treated with isotretinoin combined with DPL.All the three groups were treated for 12 weeks,and the clinical efficacy and skin lesion scores were observed.The dermatological quality of life index(DLQI)of the three groups before and after treatment was compared,and the occurrence of adverse reactions(erythema aggravation,pigmentation,papule increase/area increase,and other gastrointestinal reactions)was counted.Results The total effective rate was 65.00%(13/20)in group A,75.00%(15/20)in group B,and 95.00%(19/20)in group C.The difference was statistically significant(P<0.05);DLQI scores in group C decreased gradually with the course of treatment,and were lower than those in groups A and B at the same period(P<0.05);After treatment,the skin lesion scores of the three groups decreased compared with those before treatment,and group C was better than group A and B(P<0.05);The incidence of adverse reactions in group C was lower than that in groups A and B(P<0.05).Conclusions Both precision light and isotretinoin have shown good effects in the treatment of rosacea,and the combination of the two has better efficacy and high safety,which has a positive effect on improving the quality of life of patients with rosacea and improving the symptoms of skin lesions,and is worthy of clinical application.
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维普
