Clinical effects of dye pulsed light combined with tranexamic acid in the treatment of melasma of melanized with vascularized type
Objective To explore the clinical efficacy and safety of narrow-spectrum intense pulsed light combined with tranexamic acid in the treatment of pigment combined with vascular melasma.Methods A total of 49 patients with pigment combined with vascular melasma admitted to Suzhou Municipal Hospital from January 2021 to August 2024 were collected,including 10 cases in tranexamic acid group,18 cases in narrow-spectrum intense pulsed light group,and 21 cases in tranexamic acid combined with intense pulsed light group.The melasma area and severity score and clinical erythema rating scale were used to analyze the melasma pigment and erythema before and after treatment in the three groups.Results After treatment,the area and severity index scores of melasma lesions in three groups of patients decreased significantly compared to before treatment(P<0.01).The combination of tranexamic acid and narrow spectrum intense pulsed light group showed a significant decrease compared to the tranexamic acid group,with a statistically significant difference(P<0.05).The decrease was more significant than that in the narrow spectrum intense pulsed light group,with a statistically significant difference(P<0.01);After treatment,the erythema scores of the narrow spectrum intense pulse light group and the combination of tranexamic acid and narrow spectrum intense pulse light group decreased significantly compared to before treatment(P<0.01).The narrow spectrum intense pulse light group showed a more significant decrease than the tranexamic acid group,and the difference was statistically significant(P<0.05).The combination of tranexamic acid and narrow spectrum intense pulse light group showed a more significant decrease than the tranexamic acid group,and the difference was statistically significant(P<0.05).No serious adverse reactions or recurrence cases were observed in all three groups.Conclusions Dye pulsed light combined with tranexamic acid in the treatment of pigment combined with vascular melasma is safe and effective,worthy of clinical promotion
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