Objective:To compare the application effects of Trima and Amicus blood cell separators.Methods:63 blood donors who were received by this blood station from March 2022 to March 2023 were selected.Blood samples were collected and analyzed using Trima and Amicus blood cell separators,and their(Trima group and Amicus group)application effects were compared.Results:There was no significant difference in platelet indicators,blood routine indicators,processed whole blood volume,and collection efficiency between Trima group and Amicus group(P>0.05).The incidence of adverse reactions in Amicus group was lower than that in Trima group,and the difference was statistically significant(P<0.05);The collection time of Trima group was lower than that of Amicus group,the residual blood volume of pipeline was lower than that of Amicus group,and the use of anticoagulant was higher than that of Amicus group,with statistical significance(P<0.05).Conclusion:The use of Trima and Amicus blood cell separators for collection has both advantages and disadvantages,such as short Trima collection time and fewer adverse reactions to Amicus.Therefore,in the process of practical clinical application,appropriate blood cell separators should be selected based on the actual situation and needs to promote the improvement of application effectiveness.