Evaluation Value of CT Perfusion Imaging for Prognosis of Patients with Primary Liver Cancer After Interventional Therapy
Objective:To evaluate the prognostic value of CT perfusion imaging(CTPI)in patients with primary liver cancer after interventional therapy.Methods:A total of 150 patients with primary liver cancer who received TACE treatment in our hospital from January 2019 to January 2022 were selected as research objects.CTPI examinations were performed before TACE and one week after TACE,and parameters such as hepatic blood flow(HBF),hepatic artery perfusion volume(HAP),peak time(TTP),and hepatic artery perfusion index(HPI)were obtained.According to the short-term prognosis of TACE,all enrolled patients were divided into objective response group(n=97)and non-response group(n=53).The differences of CTPI parameter values and blood tumor indexes were compared and the correlation was analyzed.After long-term follow-up,the patients were divided into survival group(n=31)and death group(n=119).The difference of CTPI parameters was compared and the early warning value of this index for survival prognosis was analyzed.Results:After 3 months of treatment,HBF,HAP and HPI in objective remission group were lower than those in non-remission group,while TTP was higher than those in non-remission group(P<0.05).The levels of AFP,VEGF and MMP-9 in peripheral blood were lower than those in non-remission group(P<0.05).Pearson test showed that HBF,HAP and HPI were positively correlated with blood AFP,VEGF and MMP-9 levels in patients with primary liver cancer,while TTP was negatively correlated with blood AFP,VEGF and MMP-9 levels(P<0.05).3 months after treatment,HBF,HAP and HPI in the survival group were lower than those in the death group,while TTP was higher than those in the death group(P<0.05).ROC curve showed that HBF,HAP,HPI and TTP had early predictive value for TACE survival in patients with primary liver cancer,respectively.Conclusion:CTPI parameter value detection is related to the short-term efficacy of TACE in patients with primary liver cancer,and has certain value in predicting the long-term survival outcome of patients.
万方数据
维普
