Objective:To evaluate the biocompatibility of cross-linked sodium hyaluronate gel for injection.Methods:The biocompatibility of cross-linked sodium hyaluronate gel for injection was evaluated by cytotoxicity test,sensitization test,intradermal reaction test,acute toxicity test,genetic toxicity test,implantation test and chronic toxicity test.Results:The test results showed that the cross-linked sodium hyaluronate gel for injection had mild cytotoxicity,no sensitization reaction,no genetic toxicity,no acute and chronic toxic reaction,the intradermal reaction score was l.5,and the scores of each stage in the implantation test were 3.08,1.83,0.33 and 0 at week 4,13,26 and 52,of the implantation test,the degradation was basically completed in 52 weeks.Conclusion:The cross-linked sodium hyaluronate gel for injection has mild adverse effects on local tissues,but no systemic toxicity and genotoxicity.
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