Objective:To analyze the failure information,failure types and causes of the pre-vacuum pressure steam sterilizer in the central sterile supply department,and to formulate corresponding management measures,so as to reduce the alarm frequency of the sterilizing equipment.Methods:To collect and analyze retrospectively the between January 2019 and September 2019 during three alarm frequency in the process of the vacuum pressure steam sterilizer and fault information,through the continuous quality improvement method was established,the sterilization core management team,post after improving measures such as training,collect and analyze during October 2019 to June 2020 alarm frequency and fault information,compare the two.Results:The first 5 pre vacuum pressure steam sterilizers were improved,with a total of 61 alarms.Among them,25 were caused by the lack of water,electricity,and steam supply conditions,28 were operated improperly,and the equipment itself malfunctioned 8 times;After improvement,there were a total of 15 alarms,among which 3 were caused by missing water,electricity,and steam supply conditions,5 were caused by non-standard operations,and 7 were caused by equipment malfunctions,with a statistically significant difference(P<0.05).Conclusion:By standardizing the scientific management and improving the system,the alarm frequency of the pre-vacuum pressure steam sterilizer can be reduced and the service life of the sterilizer can be prolonged.