A Study on the Analgesic Effect of Lidocaine Cataplasms(Debaining?)Application for Aminolevulinic Acid-Based Photodynamic Therapy
Objective:To study whether the use of Lidocaine Cataplasms(Debaining®)after applying ALA to the affected area can effectively reduce the pain of photodynamic therapy.And whether it affects the effect of photodynamic therapy.Methods:A total of 9 cases(from August 1st,2020,to July 31,2021)of generalised female vulvar condyloma acuminatum patients attending our clinic were enrolled as the observation objects.Using the self-control method,each patient was treated for 4 times with an interval of 7-14 days.2 of the 4 treatments were randomly selected as the treatment group.In this group,lidocaine cataplasms(Debaining®)were used to cover the lesion for 3 hours prior to the procedure.In the control group,the affected area was isolated and sealed with cling film under the lidocaine cataplasms.Drug absorption was assessed before operation,and pain was assessed by VAS score during operation.Lesion clearance was compared after operation.Results:There was no significant difference in fluorescence diagnostic visualisation between the treatment group and the control group after drug application.The pain VAS score was(6.7±1.6)in the treatment group,and(8.1±1.9)in the control group,and the difference was statistically significant(P＜0.01).The lesion clearance rate after single treatment was 61.78％in the treatment group,and 60.22％in the control group,with no statistically significant difference(P＞0.05).Conclusion:Lidocaine cataplasms is easy to use,does not affect the absorption of ALA,and does not interfere with the therapeutic effect,suggesting that it may play a role in pain control during treatment.
万方数据
维普
