Application Study of Dual Energy CT Imaging Iodogram Parameters in Distinguishing Benign and Malignant Solitary Pulmonary Nodules
Objective:To study the application of dual energy CT imaging iodine map parameters in distinguishing benign and malignant solitary pulmonary nodules(SPN).Methods:A retrospective analysis was conducted on 64 SPN patients admitted to Dongguan Songshan Lake Central Hospital from March 2023 to October 2023.According to the pathological biopsy results,patients were divided into a benign group(n=34 cases)and a malignant group(n=30 cases).All patients underwent dual energy CT scans during the arterial phase and venous phase,and the iodine map parameters[arterial iodine coverage value(AOL),arterial iodine concentration(AIC),arterial standardized iodine concentration(ANIC),venous iodine coverage value(VOL),venous iodine concentration(VIC),and venous standardized iodine concentration(VNIC)]were calculated.Based on pathological biopsy results,the diagnostic results of dual energy CT imaging examination was analyzed.The iodine map parameters(AOL,AIC,ANIC,VOL,VIC,VNIC)between SPN patients in the benign and malignant groups were compared.And ROC was used to analyze the differential diagnostic efficacy of iodine map parameters for malignant SPN.Results:Using pathological biopsy results as the gold standard,the Kappa consistency of dual energy CT imaging iodine map parameters for qualitative diagnosis of SPN was 0.658,the diagnostic accuracy was 82.81%,the sensitivity was 76.47%,the specificity was 90.00%,and the positive predictive rate was 89.66%.There was no statistically significant difference in AOL,VOL,AIC,and VIC between SPN patients in the benign group and malignant group(P>0.05).The ANIC,VNIC,and MVD of the benign group were lower than those of the malignant group,(P<0.05).ROC analysis showed that the ROC curve areas under the diagnosis of malignant nodules by ANIC and VNIC were 0.787 and 0.770,with truncation values of 0.187 and 0.273 for ANIC and VNIC.Taking the cutoff value as the critical value and using joint detection,the curve area under ROC is 0.852,with high sensitivity(81.82%)and specificity(75.00%).Conclusion:The combined detection of ANIC and VNIC in dual energy CT imaging iodine map parameters has good diagnostic efficacy for malignant SPN,and can provide good reference value for clinical practice.
dual energy CT imaging iodine map parameterssolitary pulmonary nodulesbenignmalignant
万方数据
维普
