Objective:To analyze the sensitivity and specificity of MRI and PETCT in the differential diagnosis of lung cancer patients.Methods:A total of 108 patients with suspected lung cancer received from the hospital from January 2019 to December 2021 were selected for retrospective analysis.All patients underwent surgical pathological examination,and surgical pathological examination was taken as the gold standard,which was divided into MRI group and PETCT group according to the examination method,MRI group underwent magnetic resonance imaging technology(MRI)examination,and patients in PETCT group underwent positron emission computed tomography(PETCT)examination,and the tumor lesion characteristics,detection status and diagnostic value of both groups were observed and analyzed.Results:98 of 108 suspected lung cancer were lung cancer(90.74%),10 non-lung cancer(9.26%),98 including 28 small cell lung cancer(28.57%),35(35.71%)lung adenocarcinoma,20(20.41%)and 15(15.31%);6 of 10 non-lung lesions were lung nodules(60.00%)and 4(40.00%).No significant differences were found between the two disease types(P>0.05).The diagnostic efficacy(sensitivity,specificity,positive predictive value,negative predictive value,accuracy)under PETCT was slightly higher than MRI,but the difference in data comparison was not obvious,P>0.05.Conclusion:MRI and PETCT are similar in sensitivity and specificity,with high value can be used to diagnose lung cancer patients.