Analysis of the Distribution and Drug Resistance of Pathogenic Bacteria of Lower Respiratory Tract Infection in Patients with Nosocomial Acquired Pneumonia in a Hospital
Objective:To clarify the distribution of pathogenic bacteria in patients with lower respiratory tract infection of nosocomial acquired pneumonia in a hospital,to verify the drug resistance of pathogenic bacteria.Methods:A total of 135 patients with pneumonia and lower respiratory tract infection in a certain hospital from January 2020 to December 2022 were selected as the research subjects.First,sputum samples of patients with this disease were collected,and then the samples were subjected to general culture and drug sensitivity analysis.In the process,it is necessary to isolate pathogenic bacteria from the collected patient sputum samples and observe the distribution of pathogenic bacteria in a timely manner.Then,drug resistance testing should be conducted on the pathogenic bacteria detected from the patient sputum.Results:A total of 288 pathogenic bacteria were isolated and detected in 135 sputum samples collected from 135 patients,including Gram positive cocci,Gram negative bacilli,and fungi.Among them,the most numerous pathogenic bacteria were Gram negative bacilli,with a total of 231 strains identified,accounting for 80.21%.Gram positive cocci ranked second,with a total of 31 pathogenic bacteria,accounting for 10.76%,and fungi accounting for the least.Among the Gram negative bacterial groups,the most widely distributed is Klebsiella pneumoniae,co isolated 98 strains were identified,accounting for 42.42%;Among Gram positive cocci,the pathogen with the highest proportion is Staphylococcus aureus,with a total of 17 strains identified,accounting for 54.84%;In the pathogen resistance test conducted in this experiment,Pseudomonas aeruginosa in Gram negative bacteria showed strong resistance to the selected antibiotics in this experiment,with a resistance rate of 80.85%to the commonly used clinical drug compound Xinnuomin;Staphylococcus aureus,which has the highest number of Gram positive cocci,also shows relatively high resistance to penicillin,accounting for 82.35%.Conclusion:The application of the bacterial identification drug sensitivity analysis system can reveal that the common pathogenic bacteria in lower respiratory tract infections caused by acquired pneumonia in our hospital are mainly Gram negative bacteria,which have high resistance to antibiotics.When treating patients in clinical practice,it is necessary to consider the resistance of the pathogenic bacteria,select existing conventional antibiotics reasonably,and improve the treatment efficacy of patients.
antimicrobial susceptibility analysis systems for bacterial identificationlower respiratory tract infectionpneumoniaantimicrobial resistancepathogen distribution
万方数据
维普
