Objective:To explore the application effect of nasal high flow humidified oxygen therapy in high-risk offline patients.Methods:A total of 110 high-risk weaning patients treated with mechanical ventilation through tracheal intubation in our hospital from September 2021 to September 2023 were selected.They were randomly divided into a control group(treated with conventional nasal cannula oxygen therapy after weaning)and an observation group(treated with nasal high flow humidified oxygen therapy after weaning)using a random number table method,with 55 patients in each group.The changes in various circulatory and respiratory parameters before and 48 hours after weaning were observed in both groups,compare the success rate of offline therapy,length of hospital stay,and adverse reactions to oxygen therapy between the two groups.Results:There was no statistically significant difference in the levels of various circulatory and respiratory parameters between the two groups after 2 hours of offline work(P>0.05);The respiratory rate,heart rate,and partial pressure of carbon dioxide in the observation group after 48 hours of offline were lower than those in the control group,while blood oxygen saturation and oxygenation index were higher than those in the control group(P<0.05);The offline success rate of the observation group was 96.36%,higher than the control group's 81.82%,and the hospitalization time was shorter than that of the control group(P<0.05).Conclusion:Providing nasal high flow humidified oxygen therapy to high-risk offline patients can improve their postoperative circulation and respiratory status,increase their success rate of offline therapy,reduce adverse reactions to oxygen therapy,and shorten their hospital stay.