Objective:To explore the application effects of laparoscopic cholecystectomy(LC)and traditional cholecystectomy(CC)in acute calculous cholecystitis.Methods:Using a lottery method,50 patients with acute calculous cholecystitis in our hospital from October 2021 to October 2023 were selected and divided into a control group(CC)and an observation group(LC),with 25 cases in each group.Compare the two groups of surgical related indicators,pain status,inflammatory factors,and incidence of complications.Results:The observation group had better surgical related indicators than the control group.Compared to the control group,the observation group had lower VAS scores at 3 hours,6 hours,12 hours,and 24 hours after surgery(P<0.05).Compared to the control group,the TLR-4 and CRP levels in the observation group were lower(P<0.05).The total incidence of complications(incision infection,lung infection,bile duct injury,bile leakage)in the observation group was 12.00%,lower than that in the control group(28.00%,P<0.05).Conclusion:LC surgery is significantly better than CC surgery in the treatment of acute calculous cholecystitis patients.It can not only improve clinical indicators,reduce hospital stay,but also improve inflammatory factors.With fewer adverse reactions,it is safe.