Objective:To analyze the clinical results of endoscopic retrograde cholangiopancreatography(ERCP)and laparoscopic cholecystectomy(LC)in patients with acute biliary pancreatitis.Methods:92 patients with acute biliary pancreatitis from May 2021 to May 2023 were selected and divided into control group and observation group by randomized double-blind method.The laparoscopic cholecystectomy was given to the control group,and the observation group was treated with laparoscopic cholecystectomy to compare the efficacy of the two groups.Results:The operation time in the observation group was(54.26±8.64)min higher than that in the control group(45.41±6.52)min(P<0.05);The recovery time,length of stay,IL-6 level and hs-CRP level were(10.26±1.93)h,(3.41±0.62)d,(60.62±5.84)pg/mL,(20.13±1.84)mg/L below the(13.89±2.55)h,(4.18±0.54)d,(68.98±6.95)pg/mL,(24.58±2.43)mg/L(P<0.05)in the observation group;The incidence of complications in the observation group was 3.22%,which was lower than the 12.90%in the control group(P<0.05);The pain scores of the observation group at 12 hours,3 days,and 7 days after surgery were(4.62±0.81)points,(3.35±0.62)points,and(2.03±0.46)points,respectively,which were lower than those of the control group(5.57±0.54)points,(4.18±0.73)points,and(3.16±0.78)points(P<0.05);Satisfaction with the incision aesthetics of the observation group was 93.54%higher than 70.96%in the control group(P<0.05).Conclusion:Patients with acute biliary pancreatitis are treated with endoscopic retrograde cholangiancreatography combined with laparoscopic cholecystectomy and safe.